Tff3 receptor
WebTFF3; trefoil factor 3: Aliases: ITF, P1B, TFI : Location: 21q22.3: ... (TFF3) gene has identified putative estrogen and progesterone receptor-DNA binding domains as direct response …
Tff3 receptor
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Web1 Dec 2024 · Trefoil factor 3 (TFF3) is a small molecule polypeptide that is mainly secreted by intestinal mucus cells, and it is distributed widely in normal human tissues [1, 2].TFF3 consists of 59 amino acids and contains a characteristic three-looped structure, as shown in Fig. 1.The trefoil domain structure is composed of three intramolecular disulfide bonds … WebAryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming Lab Invest . 2024 Feb ... Tff3) associated with differentiation of the goblet cell secretory lineage. Math1 was identified as a direct target gene of AHR, a transcription factor critical to the development of goblet cells. These data suggest that ...
Web23 Sep 2013 · The molecular mechanisms of Tff3 action are still unclear. Though no binding molecule has been identified with the classical characteristics of a receptor , we speculate that Tff3 may act through a receptor-mediated way. Additional studies are required to identify putative Tff3 receptor in the future. http://www.cancerindex.org/geneweb/TFF3.htm
WebTFF3 protein expression was associated with oestrogen receptor, progesterone receptor and TFF1 expression in malignant breast cells. TFF3 is a specific and sensitive predictive … Web10 Oct 2024 · TFF3 has been reported to bind LINGO2 [34], CXCR4/7 and other as yet unidentified receptors [35]. In addition, TFF3 indirectly activates other receptors including the HER family of tyrosine kinases and insulin-like growth factor receptor 1 (IGFR1) [32], triggering a multitude of downstream
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfide bonds. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are diverse, including protection of the mucosa, thickening of the mucus, and increasing epithelial healing rates. This gene is a marker of columnar epithelium and is expressed in a variety of tissues including goblet cells of th…
Web6 Dec 2024 · The polypeptide TFF3 belongs to the trefoil factor family (TFF) of lectins. TFF3 is typically secreted from mucous epithelia together with mucins. Both intestinal and salivary TFF3 mainly exist as disulfide-linked heterodimers with IgG Fc binding protein (FCGBP). Here, we investigated bronchial tissue specimens, bronchial secretions, and … resume headlines for software testerWeb9 Jun 2024 · Goblet cells are a specialized cell type of IEC that secrete Trefoil factor 3 (TFF3) to regulate mucus viscosity and wound healing, but whether TFF3-responsiveness requires a receptor is unclear. resume headlines for customer serviceWebprotein-coupled receptors in the gastrointestinal tract Michael Dominic Chua, Gabriela Miroslavova Mineva, and Julian Andrew Guttman ... (Tff3, in green) by goblet cells of the healthy mouse colon. Tff3 is a host-produced factor critical for the maintenance of the intestinal epithelial barrier. Its expression is significantly prueba touch onlineWebTFF3 inhibitor AMPC (AMPC) Catalog No.: PC-38711 Not For Human Use, Lab Use Only. AMPC is a first-in-class small-molecule inhibitor of the oncogenic functions of trefoil factor 3 (TFF3) that specifically monomerizes dimeric TFF3 to inhibit dimeric TFF3 function, specifically binds to Cys57 of TFF3. prueba toefl online gratisWeb16 Sep 2024 · Trefoil factor family (TFF) peptides mainly consist of characteristic TFF domains, which contain about 40 amino acid residues, including 6 conserved cysteine residues. TFF peptides possess a single (mammalian TFF1 and TFF3), two (mammalian TFF2, Xenopus laevis xP2) or four TFF domains (X. laevis xP4). They exhibit lectin … resume headlines for qaWebObjectives: TFF3 has been found to be up-regulated at the gene and protein levels in endometrioid adenocarcinoma (EAC) when compared to uterine serous carcinoma (USC) … resume hedge fund analystWeb19 Aug 2024 · Furthermore, our molecular experiments indicated that hepatic Tff3 could alleviate hepatic steatosis via upregulating the expression of peroxisome proliferator-activated receptor-α (PPARα) directly, thereby enhancing the fatty acid oxidation process in the liver. Notably, we found that Tff3 attenuates the fatty liver phenotype independent of … prueba up and go