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WebJan 27, 2024 · Recent evidence demonstrates that PACCs are viable and exist as a distinct and functional cancer cell state, able to resist stress within the tumor microenvironment (5–31).This allows us to develop a unifying theory to explain cancer recurrence and lethality that builds upon and unifies the observations of multiple fields of study, including … WebSep 20, 2024 · Background The non-proliferating polyaneuploid cancer cell (PACC) state is associated with therapeutic resistance in cancer. A subset of cancer cells enters the PACC state by polyploidization and acts as cancer stem cells by undergoing depolyploidization and repopulating the tumor cell population after the therapeutic stress is relieved. flannel disney sheet
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