How does daptomycin cause myopathy

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August undefined, 2024

WebDaptomycin: Temporarily suspend simvastatin: Grapefruit juice: Avoid grapefruit juice ... Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase (CK) above ten times the upper limit of normal (ULN). Myopathy sometimes takes the form of rhabdomyolysis with or without acute renal failure … WebWhile the statins are effective in providing protection from coronary and cardiovascular events, they are known to cause myopathy (usually dose-related) and, rarely, rhabdomyolysis. 1 A clinical diagnosis of myopathy is made when there is muscle pain or weakness accompanied by a creatine kinase (CK) level more than ten times the upper …

Daptomycin - Infectious Diseases - Merck Manuals Professional Edition

WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly. NOTE: This is the Professional Version. WebMar 1, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry stools bladder pain bloody or cloudy urine blurred vision chest pain, discomfort, or tightness chills confusion cough decreased awareness or responsiveness chums online referral

Cardiomyopathy - Symptoms and causes - Mayo Clinic

WebApr 2, 2024 · Cardiomyopathy (kahr-dee-o-my-OP-uh-thee) is a disease of the heart muscle that makes it harder for the heart to pump blood to the rest of the body. Cardiomyopathy can lead to heart failure. The main types of … WebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects … WebMar 1, 2024 · irregular breathing. irregular heartbeat. irritability. itching in the genital or other skin areas. itching, pain, redness, swelling, tenderness, or warmth on the skin. … chums neo pocket waist belt

Daptomycin - an overview ScienceDirect Topics

Drug-induced myopathies - UpToDate

WebDaptomycin. Daptomycin is a cyclic lipopeptide antibiotic that has a unique mechanism of action. It binds to the bacterial cell membranes, causing rapid depolarization of the … WebMar 21, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry … chums net worthWebClinically relevant plasma concentrations of daptomycin reported to cause a significant concentration-dependent false prolongation of prothrombin time (PT) and elevation of International... chums online shopping uk curtains rt555

"WebIn terms of adverse reactions, daptomycin is known to cause elevations in creatine kinase and myopathy, though this rarely leads to rhabdomyolysis, additionally, long-term use may cause allergic pneumonitis (Beauduy & Winston, 2024a; Macdougall, 2024b ). View chapter Purchase book Recommended publications Essentials of Neuroanesthesia Book • 2024 " - How does daptomycin cause myopathy

How does daptomycin cause myopathy

Rhabdomyolysis during therapy with daptomycin - PubMed

WebMar 7, 2024 · Cubicin may cause serious side effects including: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose), … WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, …

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WebMar 7, 2024 · dizziness, trouble sleeping (insomnia), anxiety, itching or skin rash, increased sweating, or. injection site reactions (pain, discomfort, irritation, redness, or swelling). Tell your doctor if you have serious side effects of Cubicin including: muscle pain/cramps/weakness, numbness or tingling of hands or feet, WebDaptomycin can cause skeletal muscle myopathy with elevations in CPK. The percentage of patients treated with daptomycin in phase III trials who experienced muscle pain or …

WebDaptomycin injection comes as a powder to be added to fluid and injected into a vein by a doctor or nurse. It is usually given once a day. The length of your treatment depends on … WebDaptomycin has excellent coverage against gram-positive bacteria. The adverse effect profile has included rare reports of myopathy and elevated CK levels. Daptomycin is a …

WebDaptomycin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: diarrhea stomach pain difficulty falling asleep or staying asleep headache dizziness increased sweating redness, pain, or swelling at the injection site unusual weight gain sore throat Some side effects can be serious. WebJan 1, 2024 · Daptomycin for injection is indicated for the treatment of adult patients with Staphylococcus aureus bloodstream infections (bacteremia), including adult patients with right-sided infective endocarditis, caused by methicillin-susceptible and …

WebComment: Coadministration of daptomycin with HMG-CoA reductase inhibitors may increase CPK levels and risk for myopathy; consider temporary suspension of HMG-CoA …

WebDec 19, 2024 · In this retrospective, case-control study, both myopathy and rhabdomyolysis were increased by coadministration. Daptomycin has been associated with clinical myopathy in 2% to 14% of patients. Similarly, statins are associated with myopathy in 5% to 10% of patients. Although prior reports suggested no increased risk for myopathy when … chums newspaper offersWebMar 10, 2024 · Myopathy, defined as muscle aching or muscle weakness, in conjunction with increased serum CK concentrations up to 10 times ULN reported in patients receiving daptomycin. ... Daptomycin causes concentration-dependent false prolongation of the PT and elevated INR if certain recombinant thromboplastin reagents are used for these tests. chums online shopping ladies skirtsWebMar 1, 2024 · Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream (bacteremia), including right-sided infective endocarditis. Daptomycin belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. detailed lesson plan in cookery grade 12WebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant … detailed lesson plan in cookery 9WebNov 24, 2024 · It is less nephrotoxic than vancomycin. It has a unique bactericidal mechanism through destruction of bacterial membrane potential. However, one of the … detailed lesson plan in crop productionWeba disease with shrinking and weaker muscles called myopathy atrial fibrillation atrial flutter supraventricular arrhythmias, a type of abnormal heart rhythm pneumonia with high amount of... chums online shopping uk lace curtainsWebPatients often have muscle stiffness or weakness. Myositis: This is a type of myopathy that causes inflammation of your muscles, leading to weakness, swelling and pain. Many people with a myopathy, including myositis, manage their symptoms and lead active lives. Medications can often relieve symptoms. detailed lesson plan in cookery grade 10