Durocher cip2a
WebFeb 8, 2024 · CIP2A is cytoplasmic in interphase but, in mitosis, accumulates at DNA lesions as part of a complex with TOPBP1, a multifunctional genome stability factor. In … WebAug 12, 2009 · Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified human oncoprotein that inhibits c-Myc protein degradation in cancer cells. CIP2A has been found to be overexpressed in different human cancers, but its clinical relevance has not yet been established.
Durocher cip2a
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WebDurocher D, et al. The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Nature Cancer. 2: 1357-1371. PMID 35121901 DOI: ... Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB. The molecular basis of FHA domain:phosphopeptide binding … WebFeb 8, 2024 · CIP2A is actively exported from the cell nucleus in interphase but, upon nuclear envelope breakdown at the onset of mitosis, gains access to chromatin where it forms a complex with MDC1 and...
WebNov 11, 2024 · Durocher and colleagues identify CIP2A through synthetic lethal CRISPR screens as a key regulator of adaptive feedback mechanisms controlling chromosomal …
WebDaniel Durocher 53BP1 is a chromatin-binding protein that regulates the repair of DNA double-strand breaks by suppressing the nucleolytic resection of DNA termini1,2. WebDr. Philip Durocher, MD is a Family Medicine Specialist in Pontiac, MI. Dr. Durocher studied at EASTERN VIRGINIA MEDICAL SCHOOL / MEDICAL COLLEGE OF …
WebMar 26, 2024 · This study is the first to describe a pathogenic CIP2A mutation in humans, which might disrupt neuronal development via enhancing mTOR and c-Myc protein expressions, shedding light in mechanisms of Dandy-Walker variant pathogenesis. biomarker for metastasis and prognosis in clear cell renal cell carcinoma
WebbioRxiv.org - the preprint server for Biology irs change in tax yearWebformation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer. Thus, our data show that CIP2A is a human oncopro-tein that inhibits PP2A and … portable recording microphoneWebJul 16, 2024 · CIP2A is actively exported from the cell nucleus in interphase but, upon nuclear envelope breakdown at the onset of mitosis, gains access to chromatin where it … portable recording devices for musicWebThe CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Durocher and colleagues identify CIP2A through synthetic … irs change llc addressWebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn … irs change naics codeWebBenefit from Durocher International’s reliable service and expertise that has expanded to logistics over the past decades. Our logistics team is dedicated to customer satisfaction, … portable recording studio roomWebJun 16, 2011 · Cancerous inhibitor of PP2A (CIP2A) is a recently described inhibitor of PP2A in breast and gastric cancer. The aim of this study was to investigate whether CIP2A played a role in CML and whether PP2A or its inhibitor proteins CIP2A or SET could predict clinical outcome. irs change my deductions