WebJul 18, 2024 · A signaling pathway in eukaryotes known as cGAS–STING recognizes the presence of cytosolic DNA, which alerts the immune system to viral infection or cellular damage. However, the majority of DNA viruses direct their genomic DNA into nuclei, suggesting that nuclear-specific sensing is also needed. L. WebDNA has been known to be a potent immune stimulus for more than half a century. However, the underlying molecular mechanisms of DNA-triggered immune response have remained elusive until recent years. Cyclic GMP-AMP synthase (cGAS) is a major cytoplasmic DNA sensor in various types of cells that detect either invaded foreign DNA …
Assessing Mitochondrial DNA Release into the Cytosol and
WebMitochondrial DNA (mtDNA) is a particularly potent DAMP that engages multiple innate immune sensors, although mounting evidence suggests that cytosolic mtDNA is primarily detected via the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. cGAS and STING are widely expressed in mammalian cells and serve as key ... WebJul 13, 2024 · A complex interplay between innate immune sensing and DNA damage is emerging. Cells that undergo DNA damage can activate innate immune signalling by non-canonical pathways involving... biotechnology loyalist
Innate Immune DNA-Sensing Pathways - ScienceDirect
WebThe innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR), cytoplasmic, … WebNonhomologous end-joining (NHEJ) is an important pathway in the repair of DNA double strand breaks (DSBs), and the DNA-PK complex, composed of the heterodimer Ku 70/86 … WebNov 6, 2012 · Here, we demonstrate that cellular STING facilitates the recognition of aberrant cytoplasmic DNA species derived from necrotic or inappropriately apoptosed cells to trigger the production of an array of innate immune and proinflammatory genes, including type I IFN in BMDM, and other cell types. daiwa protogear a h90 プロトギア