Cst galectin-3

Author: kiru

August undefined, 2024

WebPolyclonal Antibody for studying galectin-3. Cited in 8 publications. Validated for Western Blotting. Highly specific and rigorously validated in … WebGalectin-3 is a 29 to 35 kDa chimera-type galectin − the only member of the galectin family with an extended N-terminal domain constituted of tandem repeats of short amino …

The role of galectins in immunity and infection

WebFeb 11, 2013 · Clinical significance: A galectin-3 test may be ordered for the identification of individuals with chronic heart failure at elevated risk of disease progression. Limitations: … WebMay 13, 2010 · GCS-100 is a galectin-3 antagonist with an acceptable human safety profile that has been demonstrated to have an antimyeloma effect in the context of bortezomib resistance. In the present study, the mechanisms of action of GCS-100 are elucidated in myeloma cell lines and primary tumor cells. onslow what to do

LGALS3BP - Wikipedia

WebGalectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene. Function. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Using fluorescence in–situ hybridization, the full length 90K cDNA has been localized to chromosome 17q25. WebGalectin-3 (Gal-3) is a 29–35-kDa β-galactoside-binding protein that was identified in macrophages in multiple tissues, such as heart, liver, and kidney (Barondes et al., 1994; Henderson et al., 2008 ). Experimental studies have shown that Gal-3 plays an important role in cardiac fibrosis and the development of CHF ( Sharma et al., 2004 ). WebApr 1, 2024 · Galectin-3 is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and whose expression correlates with poor survival particularly in patients with non–small cell lung cancer (NSCLC). To examine the role of galectin-3 inhibition in NSCLC, we tested the effects of galectin-3 depletion ... ioft2020

An Orally Active Galectin-3 Antagonist Inhibits Lung …

Galectin-3/LGALS3 Antibody Cell Signaling Technology

WebMar 21, 2024 · LGALS3 (Galectin 3) is a Protein Coding gene. Diseases associated with LGALS3 include Follicular Adenoma and Papillary Carcinoma.Among its related pathways are Gene expression (Transcription) and Innate Immune System.Gene Ontology (GO) annotations related to this gene include RNA binding and chemoattractant activity.An … WebMay 12, 2024 · Gal-3 regulates the half-life of subsets of mRNAs with shared functions. We first aimed to obtain a global view of the action of Galectin-3 as a post-transcriptional regulator in epithelial cells. io ftWebgalactose residues [1]. Galectin- 3 is the only known member of a family of chimera-type galectins which contains a C-terminal carbohydrate recognition domain (CRD) for sugar … onslow winschoten

"WebApr 5, 2015 · The second protein, galectin-3, is a galactoside-binding protein and a known cancer-associated protein secreted by a number of tumor types ( 15 ). Galectin-3, like … " - Cst galectin-3

Cst galectin-3

Galectin-3 expression and secretion by tumor-associated macrophages …

WebJan 26, 2024 · Galectin-3 (Gal-3) regulates basic cellular functions such as cell-cell and cell-matrix interactions, growth, proliferation, differentiation, and inflammation. It is not … WebNational Center for Biotechnology Information

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WebFeb 7, 2024 · During obesity, hematopoietic cell-derived galectin 3 induces insulin resistance. While the role of galectin 3 expressed in islet-invading immune cells in both type-1 and type-2 diabetes has been studied, the importance of the expression of this molecule on the target pancreatic β cells has not been defined. Webgalectin-3 Antibodies Santa Cruz Biotechnology, Inc. offers a broad range of galectin-3 antibodies. Select galectin-3 antibodies from monoclonal antibodies listed below. View …

WebMar 12, 2015 · Galectin-3–binding protein (gal3bp), a 60- to 90-kDa protein, and its receptor/ligand, galectin-3 (gal3), a ∼35-kDa protein, are secreted proteins that can interact with each other to promote cell-to-cell adhesion and initiate pathologic, proinflammatory signaling cascades. 5-8 Both gal3bp and gal3 are found in most normal adult tissues, … WebGalectin-3 belongs to the family of water-soluble lectins, which are sugar binding proteins. Galectins preferentially bind to β-galactoside derivatives, and can cross link surface glycoproteins by binding galactose residues [1]. Galectin- 3 is the only known member of a family of chimera-type galectins which

WebSep 25, 2014 · Galectin-3 has a relatively high level of expression in triple-negative breast cancers and is a potential marker for this disease. However, the clinical and prognostic implications of galectin-3 expression in breast cancer remain unclear. We examined mastectomy specimens from 1086 breast cancer cases and matching, adjacent non … WebNational Center for Biotechnology Information

WebJul 23, 2024 · Galectin-3 also promotes caspase-11 activation and gasdermin D cleavage in macrophages treated with outer membrane vesicles, which are known to be taken up by cells and release LPSs into the cytosol. Coimmunoprecipitation confirmed that galectin-3 associates with caspase-11 after intracellular delivery of LPSs.

WebGalectin-3 is a carbohydrate-binding lectin whose expression is associated with inflammatory cells including macrophages, neutrophils, and mast cells. Galectin-3 has been linked to cardiovascular physiological processes including myofibroblast proliferation, tissue repair, and cardiac remodeling in the setting of heart failure. Concentrations ... ioft 2021WebSep 1, 2024 · Dually targeting galectins and the Neu5Ac-binding domain of SARS-CoV2 shows tentative promise in several stages of the disease: preventing viral entry, … onslow wikipediaWebApr 27, 2024 · Gal-3 is a unique chimaera-type member of the galectin family. The Gal-3 gene, named LGALS3 (human locus 14q21-22), is composed of six exons and five introns spanning approximately 17 kilobases [14,15,16].There is a particular Gal-3 internal gene (GALIG) located in the second intron of LGALS3 [].Interestingly, Gal-3 and GALIG use … onslow west australiaWebMonoclonal Antibody for studying galectin-3. Cited in 18 publications. Validated for WB, IP, IHC, IF. Available in 2 sizes. Highly specific and … onslow winds community bandWebApr 15, 2024 · D, qRT-PCR analysis of Galectin-3 mRNA expression in the neuroaxis of mouse sciatic nerve containing abundant Schwann cells (n = 3). E, qRT-PCR analysis of Galectin-3 mRNA expression in DRG, PBMC, heart, lung, liver, small intestine, colon, and kidney collected from vehicle- or paclitaxel-injected mice at 2 weeks after the first … onslow western australia weatherWebNational Center for Biotechnology Information ioft2018 出展社一覧WebApr 5, 2024 · Gal-3 (galectin-3) is a member of a β-galactoside–binding lectin family, expressed in inflammatory cells, cardiac and vascular cells, kidney, and adipose tissue. Gal-3 levels are increased in the myocardium and plasma of heart failure patients. Gal-3 is a biomarker of cardiac fibrotic degeneration in animal models. iof symbole